NuQu® Cell-Based Therapy
A Nonsurgical Solution to Back Pain
NuQu, currently in clinical trials, is designed to relieve back pain by stopping and repairing the progression of degenerative disc disease before invasive surgery becomes necessary.
The Unmet Need
Back pain is one of the most prevalent medical conditions in the United States and a leading cause of disability1. For the millions of Americans who live with chronic pain as a result of spinal disc degeneration, there are few effective treatment options. They can hope that conservative methods, such as bed rest and medication, will provide relief, or they can elect to undergo costly surgical procedures that may limit mobility. In the United States alone, more than 400,000 lumbar discectomies and 500,000 spinal fusions are performed each year2. However, these treatments do not address the underlying degeneration or restore the disc to its natural function.
ISTO is developing NuQu to alleviate back pain by resolving one of the major root causes: degenerated discs. Intended for use as an early treatment option for mild to moderate spinal disc degeneration, NuQu has the potential to repair disc structure and may prevent further deterioration.
NuQu is comprised of juvenile chondrocyte cells that have been produced using ISTO’s cartilage regeneration platform.
These cells have proven to possess far greater regenerative potential than adult chondrocytes and are known to be immune-privileged3,4. During a minimally invasive, outpatient procedure, the culture-expanded cells are injected percutaneously into the nucleus of a degenerated disc simultaneously with a commercially available fibrin. The NuQu disperses throughout the disc and fills in annular fissures.
Ongoing clinical studies have shown some preliminary evidence that NuQu restores both nucleus structure and disc height5. This breakthrough approach to treatment may provide a life-changing, long-term solution to back pain, while greatly reducing both the time and cost associated with treatment and rehabilitation.
The Advantages of NuQu
- A nonsurgical, one-step approach to treatment avoids the need to remove the degenerated disc.
- Addressing the root cause of back pain may provide long-term relief
- Juvenile cell–based technology offers superior regenerative properties and integration compared to treatments that use adult cells.
- Scalable production helps to meet commercial demand.