InQu®: a novel biosynthetic bone graft extender

Unique Hybrid Scaffold

The InQu biosynthetic polymer is the only biologic bone grafting product that uniquely combines hyaluronic acid (HyA) and poly(D,L-lactide-co-glycolide) (PLGA) to form a hybrid interwoven scaffold. Both biomaterials have a long history of safe and effective clinical use.

  • HyA is known to aid essential early events in bone formation and angiogenesis, which support the normal process of endochondral ossification.1-4
  • PLGA adds compressive resistance greater than collagen and superior handling over calcium-based ceramics.

Mechanism of Action

This is a representation of the process of endochondral bone formation that begins after InQu® (yellow and white) has been used to surgically repair a bone defect (purple) ultimately resulting in new mature lamellar bone (light blue).

moa inqu

InQu containing integrated hyaluronic acid (HyA) is shown filling a bony defect.

moa HyA Fragment

Release of HyA from InQu supports migration of marrow-derived stem cells (MSCs); attachment and proliferation of MSCs is observed within the porous structure of InQu.


moa 1Chondrogenic differentiation of MSCs ensues, forming a short-lived cartilage intermediate.moa 2Once vascularized, the cartilage calcifies and is replaced by newly woven bone.moa 3Maturation of woven bone completes regeneration of damaged bone within the InQu treated defect.


The InQu Advantage

  • Indicated for use as a bone graft extender in spinal procedures.
  • InQu has achieved biomechanical and radiographic equivalence to autograft in posterolateral fusion in preclinical studies.
  • PLGA and integrated HyA provide a microenvironment that is biocompatible and conducive to new bone formation, which leads to reliable and predictable fusion equivalent to that of autograft.
  • The hybrid scaffold supports endochondral ossification as shown in preclinical studies.
  • The PLGA component provides compressive resistance to maximize the product's bulking properties.
  • The rate of InQu resorption is consistent with the rate of bone remodeling at the site of implantation, resulting in accelerated healing as shown in preclinical studies.
  • The unique InQu biomaterial is designed to optimize application and contouring within the anatomy of the spine.
  • InQu is radiolucent which allows unobscured radiographic monitoring of the healing process.
  • InQu is available in three configurations (Paste Mix, Matrix, and Granules) to meet your a wide variety of procedural needs.


Posterolateral Fusion: Rabbit spine at 6 months postoperatively

bone graft extender
InQu Bone Graft Extender

InQu is a biosynthetic polymer that is a hybrid of two interwoven component parts: a natural polysaccharide, hyaluronic acid, and a synthetic polymer, PLGA. This unique hybrid scaffold provides an ideal microenvironment promoting reliable spinal fusion.

InQu is biocompatible, easy to handle and cost effective.


Multiple Configurations Available

InQu is available in a variety of forms - Granules, Matrix, and Paste Mix - to provide a product that best fits your needs for performing a spinal fusion procedure.

  • Paste Mix - highly moldable mixture for application in tight spaces such as those found in interbody spinal fusion cages.
  • Matrix strips - easily shaped for combination with local bone.
  • Granules - appropriately sized to fill large spaces found in spine, extremities, and pelvis.

All configurations come in different volumes or sizes so that the appropriate size can be prepared for the surgery, minimizing waste. InQu may be combined with bone marrow aspirate, blood, or other bodily fluids.


Indications for Use: InQu is a resorbable bone void filler intended to fill bony gaps or voids that are not intrinsic to the stability of the bony structure. InQu is intended for use as a bone graft substitute in the skeletal system (extremities and pelvis), and as a bone graft extender in the spine when combined with bone autograft. These defects may be surgically created or result from traumatic injury to the bone.


1. Hall CL et al. J Cell Biol 1994; 126:575-88.
2. Sasaki T et al. Bone 1995; 16:9-15.
3. Huang L et al. J Biomed Mater Res 2003; 66:880-84.
4. West DC et al. Science 1985; 14:1324-26.


To order, call Customer Service at 1-888-705-ISTO (4786)
Paste MixGranules
2.5 cc paste mixIQSP-PM-102IQSP-GR-110
InQu® is a registered trademark of ISTO Technologies, Inc. Patents pending.

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