The InQu biosynthetic polymer is the only biologic bone grafting product that uniquely combines hyaluronic acid (HyA) and poly(D,L-lactide-co-glycolide) (PLGA) to form a hybrid interwoven scaffold. Both biomaterials have a long history of safe and effective clinical use.
Mechanism of Action
This is a representation of the process of endochondral bone formation that begins after InQu® (yellow and white) has been used to surgically repair a bone defect (purple) ultimately resulting in new mature lamellar bone (light blue).
InQu containing integrated hyaluronic acid (HyA) is shown filling a bony defect.
Release of HyA from InQu supports migration of marrow-derived stem cells (MSCs); attachment and proliferation of MSCs is observed within the porous structure of InQu.
|Chondrogenic differentiation of MSCs ensues, forming a short-lived cartilage intermediate.||Once vascularized, the cartilage calcifies and is replaced by newly woven bone.||Maturation of woven bone completes regeneration of damaged bone within the InQu treated defect.|
Posterolateral Fusion: Rabbit spine at 6 months postoperatively
InQu is a biosynthetic polymer that is a hybrid of two interwoven component parts: a natural polysaccharide, hyaluronic acid, and a synthetic polymer, PLGA. This unique hybrid scaffold provides an ideal microenvironment promoting reliable spinal fusion.
InQu is biocompatible, easy to handle and cost effective.
InQu is available in a variety of forms - Granules, Matrix, and Paste Mix - to provide a product that best fits your needs for performing a spinal fusion procedure.
All configurations come in different volumes or sizes so that the appropriate size can be prepared for the surgery, minimizing waste. InQu may be combined with bone marrow aspirate, blood, or other bodily fluids.
Indications for Use: InQu is a resorbable bone void filler intended to fill bony gaps or voids that are not intrinsic to the stability of the bony structure. InQu is intended for use as a bone graft substitute in the skeletal system (extremities and pelvis), and as a bone graft extender in the spine when combined with bone autograft. These defects may be surgically created or result from traumatic injury to the bone.
1. Hall CL et al. J Cell Biol 1994; 126:575-88.
2. Sasaki T et al. Bone 1995; 16:9-15.
3. Huang L et al. J Biomed Mater Res 2003; 66:880-84.
4. West DC et al. Science 1985; 14:1324-26.
To order, call Customer Service at 1-888-705-ISTO (4786)
|InQu® is a registered trademark of ISTO Technologies, Inc. Patents pending.|