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DeNovo® ET Living Cartilage Implant

DeNovo® ET Engineered Tissue Graft is a separate technology from the DeNovo® NT Natural Tissue Graft. The DeNovo NT Graft is a minimally manipulated allograft tissue product that is commercially available in the US through Zimmer, Inc. For more information about DeNovo NT Graft, please click here.

NOTE: DeNovo® ET is an investigational product. ISTO Technologies is currently enrolling patients in a Phase III clinical trial. For more information about this study, please click here or go to www.repairmyknee.com.

	DeNovo® ET is a scaffold-free living cartilage implant designed as an off-the-shelf product to repair and regenerate damaged knee cartilage. ISTO Technologies uses a patented, juvenile cell-based technology to produce DeNovo ET implants. Juvenile cartilage cells have far superior regenerative properties than adult cartilage cells (1). ISTO's patented cell-based technology harnesses the natural healing power of juvenile cartilage cells to create a living cartilage implant. The resulting implant exhibits biochemical properties similar to those of articular cartilage found in young, healthy joints (1,2). Furthermore, recent findings have demonstrated that allogeneic chondrocytes are immune privileged and may be transplanted without risk of rejection (3).
	DeNovo ET offers distinct advantages
	Patented juvenile cell-based technology that has proved to have superior regenerative properties to adult cartilage cells Living juvenile cartilage implant may offer better integration of cartilage into host tissue Scaffold-free hyaline cartilage is similar to cartilage in young, healthy joints Single-step application procedure; one surgery incurs less trauma. Easy to use; implant glues into place Patented cell expansion technology allows for scalable implant production to meet worldwide demand
1. Adkisson HD, 4th, Martin JA, Amendola RL, Milliman C, Mauch KA, Katwal AB, Seyedin M. Amendola A, Buckwalter, JA, Streeter, PR. The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. Amer J Sports Med. 2010; 38:1324-1333. 2. Adkisson, H.D., Gillis, M.P., Davis, E.C., Maloney, W.J., and Hruska, K.A. In vitro generation of scaffold independent neocartilage. Clin Orthop Rel Res 391S: S280-S294, 2001. 3. Adkisson, HD, Milliman C, Zhang X, Mauch K, Maziarz RT, Streeter PR. Immune evasion by neocartilage-derived chondrocytes: Implications for biologic repair of joint articular cartilage. Stem Cell Research 4:57-68, 2010.