ISTO's Biomaterial-based Platform Technology

ISTO Technologies has developed a biomaterial platform for tissue repair. This technology enables the company to develop a variety of scaffold-based products for tissue engineering applications. ISTO’s platform technology is a patented biomaterial composed of synthetic poly(lactide-co-glycolide) (PLGA) and hyaluronic acid (HyA). PLGA is an excellent biomaterial for constructing three-dimensional tissue scaffolds; however, because of its innate hydrophobicity it is not optimal for cell penetration and attachment(1).  To overcome this limitation, ISTO developed a process whereby HyA is entangled within the PLGA backbone structure, creating a hydrophilic scaffold that supports migration and attachment of cells (2,3). In addition to facilitating exchange of water and ions within tissues, HyA is reported to play a central role in skeletal development and tissue repair (4-6). The first commercial application of this technology is for bone healing. 

  1. Athanasiou KA, Neiderauer G, Agrawal CM.  Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials 1996; 17:93-102.
  2. Ogston AG, Sherman TF. Effects of hyaluronic acid upon diffusión of solutes and flow of solvent. J Physiol 1961; 17:1-8.
  3. Hall CL, Wang C, Lange LA, Turley EA. Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity. J Cell Biol 1994; 126:575-588.
  4. Toole BP. Hyaluronan in morphogenesis. J Intern Med 1997; 242:35-40.
  5. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Rep Regen 1999; 7:79-89.
  6. Sasaki T, Watanabe C. Stimulation of osteoinduction in bone wound healing by high-molecular weight hyaluronic acid. Bone 1995; 16:9-15.





 

 

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